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1 Wilkinson, J. L.; Boxall, A. B. A.; Kolpin, D. W.; Leung, K. M. Y.; Lai, R. W. S.; Galban-Malagon, C.; Adell, A. D.; Mondon, J.; Metian, M.; Marchant, R. A.; Bouzas-Monroy, A.; Cuni-Sanchez, A.; Coors, A.; Carriquiriborde, P.; Rojo, M.; Gordon, C.; Cara, M.; Moermond, M.; Luarte, T.; Petrosyan, V.; Perikhanyan, Y.; Mahon, C. S.; McGurk, C. J.; Hofmann, T.; Kormoker, T.; Iniguez, V.; Guzman-Otazo, J.; Tavares, J. L.; De Figueiredo, F. G.; Razzolini, M. T. P.; Dougnon, V.; Gbaguidi, G.; Traore, O.; Blais, J. M.; Kimpe, L. E.; Wong, M.; Wong, D.; Ntchantcho, R.; Pizarro, J.; Ying, G.-G.; Chen, C.-E.; Paez, M.; Martinez-Lara, J.; Otamonga, J.-P.; Pote, J.; Ifo, S. A.; Wilson, P.; Echeverria-Saenz, S.; Udikovic-Kolic, N.; Milakovic, M.; Fatta-Kassinos, D.; Ioannou-Ttofa, L.; Belusova, V.; Vymazal, J.; Cardenas-Bustamante, M.; Kassa, B. A.; Garric, J.; Chaumot, A.; Gibba, P.; Kunchulia, I.; Seidensticker, S.; Lyberatos, G.; Halldorsson, H. P.; Melling, M.; Shashidhar, T.; Lamba, M.; Nastiti, A.; Supriatin, A.; Pourang, N.; Abedini, A.; Abdullah, O.; Gharbia, S. S.; Pilla, F.; Chefetz, B.; Topaz, T.; Yao, K. M.; Aubakirova, B.; Beisenova, R.; Olaka, L.; Mulu, J. K.; Chatanga, P.; Ntuli, V.; Blama, N. T.; Sherif, S.; Aris, A. Z.; Looi, L. J.; Niang, M.; Traore, S. T.; Oldenkamp, R.; Ogunbanwo, O.; Ashfaq, M.; Iqbal, M.; Abdeen, Z.; O’Dea, A.; Morales-Saldana, J. M.; Custodio, M.; de la Cruz, H.; Navarrete, I.; Carvalho, F.; Gogra, A. B.; Koroma, B. M.; Cerkvenik-Flajs, V.; Gombac, M.; Thwala, M.; Choi, K.; Kang, H.; Ladu, J. L. C.; Rico, A.; Amerasinghe, Priyanie; Sobek, A.; Horlitz, G.; Zenker, A. K.; King, A. C.; Jiang, J.-J.; Kariuki, R.; Tumbo, M.; Tezel, U.; Onay, T. T.; Lejju, J. B.; Vystavna, Y.; Vergeles, Y.; Heinzen, H.; Perez-Parada, A.; Sims, D. B.; Figy, M.; Good, D.; Teta, C. 2022. Pharmaceutical pollution of the world’s rivers. Proceedings of the National Academy of Sciences of the United States of America, 119(8):e2113947119. [doi: https://doi.org/10.1073/pnas.2113947119]
Pharmaceutical pollution ; Rivers ; Water pollution ; Contamination ; Aquatic environment ; Antimicrobials ; Environmental health ; Human health ; Environmental monitoring ; Wastewater ; Socioeconomic aspects ; National income ; Datasets
(Location: IWMI HQ Call no: e-copy only Record No: H050958)
https://www.pnas.org/content/pnas/119/8/e2113947119.full.pdf
https://vlibrary.iwmi.org/pdf/H050958.pdf
(6.14 MB) (6.14 MB)
Environmental exposure to active pharmaceutical ingredients (APIs) can have negative effects on the health of ecosystems and humans. While numerous studies have monitored APIs in rivers, these employ different analytical methods, measure different APIs, and have ignored many of the countries of the world. This makes it difficult to quantify the scale of the problem from a global perspective. Furthermore, comparison of the existing data, generated for different studies/regions/continents, is challenging due to the vast differences between the analytical methodologies employed. Here, we present a global-scale study of API pollution in 258 of the world’s rivers, representing the environmental influence of 471.4 million people across 137 geographic regions. Samples were obtained from 1,052 locations in 104 countries (representing all continents and 36 countries not previously studied for API contamination) and analyzed for 61 APIs. Highest cumulative API concentrations were observed in sub-Saharan Africa, south Asia, and South America. The most contaminated sites were in low- to middle-income countries and were associated with areas with poor wastewater and waste management infrastructure and pharmaceutical manufacturing. The most frequently detected APIs were carbamazepine, metformin, and caffeine (a compound also arising from lifestyle use), which were detected at over half of the sites monitored. Concentrations of at least one API at 25.7% of the sampling sites were greater than concentrations considered safe for aquatic organisms, or which are of concern in terms of selection for antimicrobial resistance. Therefore, pharmaceutical pollution poses a global threat to environmental and human health, as well as to delivery of the United Nations Sustainable Development Goals.

2 Yalin, D.; Craddock, H. A.; Assouline, S.; Mordechay, E. B.; Ben-Gal, A.; Bernstein, N.; Chaudhry, R. M.; Chefetz, B.; Fatta-Kassinos, D.; Gawlik, B. M.; Hamilton, K. A.; Khalifa, L.; Kisekka, I.; Klapp, I.; Korach-Rechtman, H.; Kurtzman, D.; Levy, G. J.; Meffettone, R.; Malato, S.; Manaia, C. M.; Manoli, K.; Moshe, O. F.; Rimelman, A.; Rizzo, L.; Sedlak, D. L.; Shnit-Orland, M.; Shtull-Trauring, E.; Tarchitzky, J.; Welch-White, V.; Williams, C.; McLain, J.; Cytryn, E. 2023. Mitigating risks and maximizing sustainability of treated wastewater reuse for irrigation. Water Research X, 21:100203. (Online first) [doi: https://doi.org/10.1016/j.wroa.2023.100203]
Wastewater treatment plants ; Water reuse ; Mitigation ; Sustainability ; Irrigation water ; Agronomic characters ; Electrical conductivity ; Organic matter ; Stakeholders ; Public health ; Salinity ; Risk assessment ; Antimicrobials ; Sewage
(Location: IWMI HQ Call no: e-copy only Record No: H052295)
https://www.sciencedirect.com/science/article/pii/S2589914723000397/pdfft?md5=e8be35eb1b9cd59e04a3a9f323d06ff9&pid=1-s2.0-S2589914723000397-main.pdf
https://vlibrary.iwmi.org/pdf/H052295.pdf
(1.07 MB) (1.07 MB)
Scarcity of freshwater for agriculture has led to increased utilization of treated wastewater (TWW), establishing it as a significant and reliable source of irrigation water. However, years of research indicate that if not managed adequately, TWW may deleteriously affect soil functioning and plant productivity, and pose a hazard to human and environmental health. This review leverages the experience of researchers, stakeholders, and policymakers from Israel, the United-States, and Europe to present a holistic, multidisciplinary perspective on maximizing the benefits from municipal TWW use for irrigation. We specifically draw on the extensive knowledge gained in Israel, a world leader in agricultural TWW implementation. The first two sections of the work set the foundation for understanding current challenges involved with the use of TWW, detailing known and emerging agronomic and environmental issues (such as salinity and phytotoxicity) and public health risks (such as contaminants of emerging concern and pathogens). The work then presents solutions to address these challenges, including technological and agronomic management-based solutions as well as source control policies. The concluding section presents suggestions for the path forward, emphasizing the importance of improving links between research and policy, and better outreach to the public and agricultural practitioners. We use this platform as a call for action, to form a global harmonized data system that will centralize scientific findings on agronomic, environmental and public health effects of TWW irrigation. Insights from such global collaboration will help to mitigate risks, and facilitate more sustainable use of TWW for food production in the future.

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